Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration
نویسندگان
چکیده
منابع مشابه
Transforming potential and matrix stiffness co-regulate confinement sensitivity of tumor cell migration.
It is now well established that tumor cell invasion through tissue is strongly regulated by the microstructural and mechanical properties of the extracellular matrix (ECM). However, it remains unclear how these physical microenvironmental inputs are jointly processed with oncogenic lesions to drive invasion. In this study, we address this open question by combining a microfabricated polyacrylam...
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Tumor invasion and metastasis are strongly regulated by biophysical interactions between tumor cells and the extracellular matrix (ECM). While the influence of ECM stiffness on cell migration, adhesion, and contractility has been extensively studied in 2D culture, extension of this concept to 3D cultures that more closely resemble tissue has proven challenging, because perturbations that change...
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CELL BIOLOGY. For the article ‘‘The expression level of the voltage-dependent anion channel controls life and death of the cell,’’ by Salah Abu-Hamad, Sara Sivan, and Varda ShoshanBarmatz, which appeared in issue 15, April 11, 2006, of Proc Natl Acad Sci USA (103:5787–5792; first published April 3, 2006; 10.1073 pnas.0600103103), the authors note that the percentages presented in the legend for...
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ژورنال
عنوان ژورنال: Integrative Biology
سال: 2013
ISSN: 1757-9694,1757-9708
DOI: 10.1039/c3ib40017d